Klinisk Biokemi i Norden Nr 2, vol. 26, 2014 - page 15

KliniskBiokemi i Norden · 2 2014
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Tabel 2. Direkte fibrosemarkører
Marker
Name
Function
ECM formation
PICP
Procollagen type I caboxy-terminal
peptide
Matrixdeposition
PINP
Procollagen type IN terminal peptide
Matrixdeposition
PIIINP
Procollagen type IIIN terminal peptide Matrixdeposition
Type IVcollagen
Basementmembrane formation
HA
Hyaluronicacid
Component ofECM
Laminin
Glycoproteindeposited inbasement
membrane
MFAP
Microfibrillar-associatedprotein
Glycoprotein involved inECM turnover
P4NP7S
N-terminal pro-peptideof type IV
collagen7Sdomain
7SdomainofCollagenType IV fragment
PVCP
Propeptideof collagen typeV
YKL-40
3N terminal aminoacids (tyrosine (Y),
lysine (K) and leucine (L))-40 (kDa)
(Humancartilageglycoprotein-39)
Growth factor for fibroblasts and
vascular endothelial cells
Fibrolyticprocess
MMP-1/MMP-13 Matrixmetalloproteinase-1/-13
Degrade fibroticmatrix
MMP-2
Matrixmetalloproteinase-2
Degradesbasalmembranes and fibroticmatrix
MMP-9
Matrixmetalloproteinase-9
Degradesbasalmembranes
TIMP-1
Tissue inhibitorofmetalloproteinase
InhibitsMMP-1activity
ECMdegradation
CO1-764
Collagen type I fragment generated
byMMP-2,9,13
Degradationproduct
CO3-610
Collagen type III fragment generated
byMMP-9
Degradationproduct
C4M
Collagen type IV fragment generated
byMMP-9
Degradationproduct
CO6-MMP
Collagen typeVI fragment generated
byMMP-2,9
Degradationproduct
Cytokines
CTGF
Connective tissuegrowth factor
Potent pro-fibrogenic factor
PDGF
Platelet derivedgrowth factor
Growth factor stimulatesproliferationofHSC
TGF-β
Transforminggrowth factor
Growth factor stimulatesproductionofECM
byHSC
TNF-α
Tumornecrosis factor
Inflammatorycytokines involved in fibrogenesis
IL-4,6,8,18
Inflammatorycytokines involved in fibrogenesis
1...,5,6,7,8,9,10,11,12,13,14 16,17,18,19,20,21,22,23,24,25,...52
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