Klinisk Biokemi i Norden · 1 2016
| 25
eget laboratorium. I tillegg skal man – så sant det er
mulig – verifisere referanseintervallet lokalt. CLSI-
standarden C28-A3 gir føringer i prosessen og er
et godt utgangspunkt for laboratorier for å komme
i gang.
Referanser
1. Clinical and Laboratory Standards Institute.
Defining, establishing, and verifying reference
intervals in the clinical laboratory. CLSI docu-
ment C28-A3 2008.
2. Holmes EW, Kahn SE, Molnar PA, Bermes EW.
Verification of Reference Ranges by using a
Monte Carlo Sampling Technique. Clin Chem
1994;40:2216-22.
3. Harris EK, Boyd JC. On dividing reference data
into subgroups to produce separate reference
ranges. Clin Chem 1990;36:265-70.
4. Lahti A. Partitioning biochemical reference
data into subgroups: comparison of existing
methods. Clin Chem LabMed 2004;42:725-33.
5. Horn PS, Pesce AJ. Reference Intervals: A
User’s Guide. Washington DC; 2005: 47-57.
6. Hoffmann RG. Patients’ test for quality con-
trol. Clin Chem 1969;15:533-6.
7. Hoffmann RG. Statistics in the practice of
medicine. JAMA 1963;14:864-876.
8. Bolann BJ. Easy verification of clinical
chemistry reference intervals. Clin Chem Lab
Med 2013;51:e279-e281.
9. Arzideh F, Wosniok W, Haeckel R. A plea for
intra-laboratory reference limits. Part 2. A
bimodal retrospective concept for determi-
ning reference limits from intra-laboratory
data bases demonstrated by catalytic activity
concentrations of enzymes. Clin Chem Lab
Med 2007;45:1043-57.
10. Arzideh F, Brandhorst G, Gurr E, Hinsch W,
Hoff T, Roggenbuck L, et al. An improved indi-
rect approach for determining reference limits
from intra-laboratory data bases exemplified
by concentrations of electrolytes. J Lab Med
2009:33:52-66.
11. Arzideh F, Wosniok W, Haeckel R. Reference
limits of plasma and serum creatinine con-
centrations from intra-laboratory data bases
of several German and Italian medical cen-
tres-comparison between direct and indirect
procedures. Clin Chim Act 2010;411:215-221.
12. Wolters B, Haeckel R. Normalisierte Dar-
stellung von Referenzintervallen und andere
Excel-Tools der Arbeitsgruppe Richtwerte der
DGKL. Klinisch Chemie Mitteilungen 2012,
Heft 3:110-116.
Foto: Henrik Alfthan.
