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Klinisk Biokemi i Norden
E, Orning L. Measurement ofActive B12: a
rapid, automated assay for holotranscoba-
lamin on the Abbott AxSYM analyzer.Clin
Chem. 2008;54:567-73.
6. Morkbak AL, Hvas AM, Milman N, Nexo
E. Holotranscobalamin remains unchanged
during pregnancy. Longitudinal changes of
cobalamins and their binding proteins during
pregnancy and postpartum. Haematologica.
2007;92:1711-2.
7. Hvas AM, Morkbak AL, Nexo E. Plasma
holotranscobalamin compared with plasma
cobalamins for assessment of vitamin B12
absorption; optimisation of a non-radioac-
tive vitamin B12 absorption test (CobaSorb).
Clin Chim Acta. 2007;376:150-4.
8. Hardlei TF, Mørkbak AL, Bor MV, Bailey LB,
Hvas AM, Nexo E. Assessment of vitamin
B(12) absorption based on the accumulation
of orally administered cyanocobalamin on
transcobalamin. Clin Chem. 2010;56: 432-6.
9. Nexo E, Christensen AL, Petersen TE,
Fedosov SN. transcobalamin by ELISA. Clin
Chem. 2000;46:1643-9.
10. Nissen PH, Nordwall M, Hoffmann-Lücke E,
Sorensen BS, Nexo E. Transcobalamin defi-
ciency caused by compound heterozygosity
for two novel mutations in the TCN2 gene: a
study of two affected siblings, their brother,
and their parents. J Inherit Metab Dis. 2010
Jul 6. [Epub ahead of print].
11. Clarke R, Sherliker P, Hin H, Nexo E, Hvas
AM, Schneede J, Birks J, Ueland PM, Emmens
K, Scott JM, Molloy AM, Evans JG. Detection
of vitamin B12 deficiency in older people by
measuring vitamin B12 or the active fraction
of vitamin B12, holotranscobalamin. Clin
Chem. 2007;53:963-70.
12. Fedosov SN. Metabolic signs of vitamin
B(12) deficiency in humans: computational
model and its implications for diagnostics.
Metabolism. 2010;59:1124-38.
Foto: Henrik Alfthan, Svalbart, Norge.
