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12
| 4 | 2003
Klinisk Biokemi i Norden
Table II:
Indicative values for components in NFKK Reference Serum X, obtained in the NORIP project.
Component
Unit
Indicative value* and (standard deviation of
mean of laboratory mean)
#
traceable
to consensus mean
via CAL to
value in NORIP
certified reference
[Enzymes: IFCC 37°C]
value by DGKC 1997
Alkaline phosphatase (ALP)
U/L
72, 5 (0,7)
-
Alanine transaminase (ALT)
U/L
-
24, 2 (0,2)
Amylase
U/L
60, 7 (1,4)
-
Aspartate transaminase (AST)
U/L
25, 5 (0,2)
-
Bilirubin
µmol/L
-
8, 97 (0,04)
Creatine kinase (CK)
U/L
-
133, 3 (0,4)
HDL-cholesterol
§
mmol/L
1, 387 (0,003)
-
Lactate dehydrogenase (LD)
U/L
147, 8 (3,1)
-
Pancreatic amylase
U/L
28, 6 (0,4)
-
Phosphate
§
mmol/L
-
1, 043 (0,002)
Protein (total protein)
§
g/L
-
68, 7 (0,11)
Transferrin
g/L
2, 709 (0,025)
-
* For values in the first column, the value is the mean of laboratory means. For values in the second column, the indicative value is the mean of factors M(X)/
M(CAL) multiplied with certified reference value for CAL, where M(X) and M(CAL) is laboratory mean of X and CAL respectively.
# No expanded uncertainties can be provided for these components, however the obtained standard deviation of mean of laboratory means (SDM), from approximately
102 laboratories using routine measurement systems can be used to judge upon the reliability of the value (first column) and the reliability of the value relative to CAL
(second column). For the enzymes a lower number of laboratories were involved (ALT: 86, Amylase: 24, AST: 79, CK: 81, Pancreatic amylase: 21, ALP: 23, LD: 3 ). For
values in the second column the SDM is without the main source of uncertainty from the target value of CAL.
§ In the Nordic Trueness Project 2002, these components were re-assigned with transferred values via CAL. No significant difference between the two sets of
values was observed (p<0,05).
Table I:
Certified values for each component and their expanded uncertainties,
U
(coverage factor,
k
=2).
Component
Unit
Certified value and expanded uncertainty
U
=2·u
c
Value
U
Albumin
g/L
41, 5
2, 7
Calcium (Ca)
mmol/L
2, 325
0, 008
Cholesterol
mmol/L
5, 220
0, 023
Creatininium
µmol/L
73, 90
0, 60
Iron (Fe)
µmol/L
20, 00
0, 56
gamma-Glutamyltransferase (GGT)
U/L
35, 42
0, 95
Glucose
mmol/L
4, 405
0, 034
Potassium (K)
mmol/L
3, 732
0, 022
Magnesium (Mg)
mmol/L
0, 8100
0, 0065
Sodium (Na)
mmol/L
140, 65
0, 75
Thyroxine (T4)
nmol/L
99, 4
3, 1
Triglyceride
mmol/L
1, 287
0, 038
Carbamide (Urea)
mmol/L
4, 910
0, 026
Urate (Uric acid)
µmol/L
309, 9
5, 8
