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Klinisk Biokemi i Norden · 4 2019
Konklusion
Kendskab til kliniske biokemiske parametres døgn-
rytmer i den kliniske hverdag bidrager med en mere
præcis fortolkning af kliniske biokemiske analyse-
svar. Behovet for kendskab til døgnrytmesvingninger
er blevet aktualiseret af 24/7 samfundet med længere
ambulante åbningstider og et ønske om hurtigere
diagnostisk afklaring af patienterne på alle tider af
døgnet.
Dertil er der et behov for yderligere forskning
på området med henblik på at etablere individuelle
døgnprofiler og tidsspecifikke referenceintervaller.
Derudover kan det overvejes at give anbefalinger
om optimale prøvetagningstidspunkter for en række
parametre.
Referencer
1. Koukkari WL, Sothern RB. Introducing Bio-
logical Rhythms: Springer Netherlands; 2006.
2. Touitou Y, Haus E. Biologic Rhythms in Clini-
cal and Laboratory medicine: Springer-Verlag
Berlin Heidelberg; 1992.
3. Skene DJ, Arendt J. Human circadian rhy-
thms: physiological and therapeutic relevance
of light and melatonin. Ann Clin Biochem
2006;43:344-53.
4. Halberg F. Chronobiology. Annu Rev Physiol
1969;31:675-725.
5. Nelson W, Tong YL, Lee JK et al. Methods
for cosinor-rhythmometry. Chronobiologia
1979;6:305-23.
6. Burtis CA, Ashwood ER, Bruns DE. Tietz
Textbook of clinical chemistry and molecular
diagnostics (Fourth edition). Elsevier Sauders;
2006.
7. Van Kerkhof LW, Van Dycke KC, Jansen EH et
al. Diurnal Variation of Hormonal and Lipid
Biomarkers in a Molecular Epidemiology-Like
Setting. PLoS One 2015;10:e0135652.
8. Gamble KL, Berry R, Frank SJ et al. Circadian
clock control of endocrine factors. Nat Rev
Endocrinol 2014;10:466-75.
9. Russell W, Harrison RF, Smith N et al. Free
triiodothyronine has a distinct circadian
rhythm that is delayed but parallels thy-
rotropin levels. J Clin Endocrinol Metab
2008;93:2300-6.
10. Veldhuis JD, Johnson ML. Operating cha-
racteristics of the hypothalamo-pituitary-
gonadal axis in men: circadian, ultradian, and
pulsatile release of prolactin and its temporal
coupling with luteinizing hormone. J Clin
Endocrinol Metab 1988;67:116-23.
11. Faiman C, Winter JS. Diurnal cycles in plasma
FSH, testosterone and cortisol in men. J Clin
Endocrinol Metab 1971;33:186-92.
12. Brambilla DJ, Matsumoto AM, Araujo AB et
al. The effect of diurnal variation on clinical
measurement of serum testosterone and other
sex hormone levels in men. J Clin Endocrinol
Metab 2009;94:907-13.
13. Haus E. Chronobiology in the endocrine
system. Adv.Drug Deliv.Rev. 2007;59:985-1014.
14. Sennels HP, Jorgensen HL, Hansen AL et al.
Diurnal variation of hematology parameters
in healthy young males: the Bispebjerg study
of diurnal variations. Scand J Clin Lab Invest
2011;71:532-41.
15. Sennels HP, Jorgensen HL, Goetze JP et al.
Rhythmic 24-hour variations of frequently
used clinical biochemical parameters in
healthy young males - the Bispebjerg study of
diurnal variations. Scand. J. Clin. Lab Invest
2012;72:287-95.
16. Goetze JP, Jorgensen HL, Sennels HP et al.
Diurnal plasma concentrations of natriuretic
propeptides in healthy young males. Clin
Chem 2012;58:789-92.
17. Timm A, Fahrenkrug J, Jorgensen HL et al.
Diurnal variation of von Willebrand factor
in plasma: the Bispebjerg study of diurnal
variations. Eur J Haematol 2014;93:48-53.
18. Sennels HP, Jorgensen HL, Fahrenkrug J.
Diurnal changes of biochemical metabolic
markers in healthy young males - the Bispe-
bjerg study of diurnal variations. Scand J Clin
Lab Invest 2015;75:686-92.
19. Heegaard NH, Carlsen AL, Lilje B et al. Diur-
nal Variations of Human Circulating Cell-
Free Micro-RNA. PLoS One 2016;11:e0160577.
