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NORIP Reference intervals
Suggestions
Plasma (Li heparin)
Serum
Plasma
Low
90% CI
High
90% CI
N Low High Low High Comment
7
6-8
45
37-50
482
10
45
10
9-11
68
56-87
443
70
14
13-14
36
34-38
533
15
35
16
16-17
45
43-52
480
45
35
32-36
215
192-257
473
35
210
Results for persons participated in
55
49-62
481
308-738
175
50
400
strenuous sports during the last week
42,0
42-46
405
261-475
200
40
280
before sample collection is excluded
44,0
35-48
95
90-113
141
35
105
Roche Modular and Vitros for
serum and only Vitros for plasma
9,0
-
42
-
113
10
45
9,0
3-10
77
61-92
206
10
75
11,0
-
117
-
104
10
80
13,0
10-14
109
72-127
185
15
115
24
20-29
115
99-122
311
25
120
11
8-13
61
49-71
218
10
65
Only Roche Modular
-
-
0
105
205
-
-
0
115
255
15
| 2 | 2003
Klinisk Biokemi i Norden
Explanations to the column labels:
“Value”: Reference method values used for CAL to
correct reference values.
“Source”: NTP: Transferred value from IMEP 17-1 in
Nordic Trueness Project, 2002. DGKC: Reference met-
hod value from DGKC, 1997. NORIP: Median of CAL-
values in NORIP.
“Quality goal”: The percentages are calculated for
each component as 0.375 of total biological variation
calculated from reference intervals in this table as
[log(H) – log(L)]/4 for lognormal distributions or as
0.5*(H-L)/(H+L) for normal distributions where H (high
reference limit) minus L (low reference limit) is the
most narrow suggested reference interval for that pro-
perty.
“LOW” and “HIGH”: Low and high reference limit.
“Gender”: F-female, M-male
“Calculated”: The reference limits and 90% confi-
dence intervals (90% CI) in most cases are given with
one decimal more than is reasonable to use in practi-
ce.
“N”: Number of reference values used to calculate
reference interval.
(4) and incorporated by him in Refval 4.0. The criteria
for not partitioning is that >0.9% and <4.1% of each
of the subdistributions should be outside 2.5- and 97.5
percentiles of the common distribution.
Conclusions on gender partitioning were mostly
made using this program. Reasonable age limits have
been estimated by ‘qualified guessing’ before partitio-
ning program have evaluated the resulting subdistri-
butions according to the criteria mentioned above.
Reference intervals
Evaluation of reference intervals
Seven groups from different laboratories in Norway
have evaluated the reference intervals proposed by the
NORIP project group for all properties as presented on
the project home site (1). The results of the evaluation
were presented at a one-day meeting on 7
th
April 2003
in Oslo. Most of the suggestions from the groups
(reports on project home site) have been taken into
account in the proposal presented below.
Proposed reference intervals
The proposed reference intervals are presented in
table 1
