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CAL
Quality
Component
Unit
goal
Calculated
Target
Gen-
Serum
value Source Bias
der
Age
Low
90% CI
High
90% CI
N
Enzymes (7)
Alanine
U/L
17,8 DGKC 6,1 % F
>=18
8
6.7-8.5
46
43-49
1220
aminotransferase
M >=18
10
8.9-10.9
68
63-74
1080
Aspartate
U/L
23,6 NORIP 3,4 % F
>=18
13
12-13
37
35-38
1128
aminotransferase
M >=18
14
13-15
45
43-47
1012
Creatinekinase
U/L 118,8 DGKC 7,3 %
F
>=18
33
31-35
207
180-233
1048
M 18-49
50
45-54
398
351-487
397
M >=50
39
36-46
277
252-415
404
Alkaline
U/L
64,0 NORIP 4,5 % FM >=18
37
36-39
106
101-113
954
phosphatases
F
18-39
10
9-11
42
34-54
283
Gamma-glutamyl-
U/L
35,8 NTP 6,1 % F
>=40
11
10-11
77
64-81
445
transferase
M 18-39
12
10-13
78
56-168
244
M >=40
15
14-16
114
99-134
409
Total amylase
U/L
55,4 NORIP 6,4 % FM >=18
27
25-29
118
113-124
719
Pancreatic amylase U/L
27,0 NORIP 7,6 % FM >=18
11
6-13
64
54-68
497
Lactate
U/L
141 NORIP 2,7 % FM 18-69 103
90-106
204
198-210
372
dehydrogenase
>=70
114
-
255
-
87
14
| 2 | 2003
Klinisk Biokemi i Norden
1. Insufficient control data for reported reference va-
lues.
2. Same samples measured by different methods on
same component.
3. Material difference: Automatic test of extreme diffe-
rences between combinations of serum, plasma,
fresh, thawed - the extreme value is excluded.
4. Person exclusions (exclusion criteria): Extreme valu-
es for one or more properties for one person exclu-
des all results for that person:
1. Glucose > 11 mmol/L, glucose > 7 mmol/L and
fasting
≥
12 hours
2. 5s/3s and 4s/4s rule: At least one result outside
median(NORIP) ± 5s for one property and at least
one value for a different property outside medi-
an(NORIP) ± 3s (5s3s rule). The same rule have
also been applied with 4s limits for both proper-
ties (s is total biological variation based on refe-
rence intervals from Malmø/Odense, logaritmic
transformations).
5. Method exclusions: Not compatible with enzyme
IFCC 37°C-methods, UIBC reported as TIBC method,
ionised calcium reported as total calcium method,
plasma with bad correlation with serum for some
methods.
6. Component specific exclusions: Non-fasting (trig-
lycerides, glucose), diabetes in near family (glucose),
physical activity (CK), oestrogen use (TIBC), values
<6 umol/L iron (iron and iron saturation).
7. Enzymes: Results outside mean + 4s (s - standard
deviation of gender partitioned distributions using
log-transformations).
8. Refval 4.0: Automatic exclusions for non-enzymes
(see "Calculation of reference intervals").
Calculation of reference intervals
Method
Simple nonparametric method have been used to cal-
culate low and high reference limits as 2.5 and 97.5
percentiles respectively of distribution of reference
values, and calculations have been done by using com-
puter program Refval 4.0 (3) based on IFCC recom-
mendations.
Partitioning
Partitioning of distribution of reference values have
been evaluated using theory outlined by Ari Lahti et al.
(Fortsat fra side 11)
