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15
| 3 | 2004
Klinisk Biokemi i Norden
The computer-based system reduced the number of
patients below the target area with 4%, increased
the number in the target area with 13% and reduced
the number of patients over the upper limit with
4%.
In a cross section survey of all patients with atrial
fibrillation in May 2004 13% were between 1.0 and
2.0 in INR (mean 1.7), 79% were in the target range
2.0 – 3.0 INR, 8% between 3.1 – 4.0 INR, 0.6% in
4.0 – 5.0 and none above 5.0.
In 692 patients treated between November 2003
and May 2004 16 had INR values above 6.0 and 3
of these were hospitalized due to bleedings, none of
which was life-threatening.
Conclusion
The system is safe to use and ensures a better
quality of treatment than the previous paper-based
system. There was no overdosing or intoxications.
50 patients can be monitored and dosed in less
than an hour.
Much time is saved on the secretarial level.
The system is now installed in all six hospitals in
Vejle County. The County´s health authorities will
offer the system for general practicians as well
– free of charge.
A detailed description of the system can be seen at
www.intramal.com
References
1) Lassen JF, Kjeldsen J, Antonsen S, Hyltoft
Petersen P, Brandslund I.
Interpretation of serial measurements of inter-
national normalized ratio for prothrombin
times inmonitoring oral anticoagulant therapy.
Clin Chem. 1995 Aug;41(8 Pt 1):1171-6.
2) Lassen JF, Brandslund I, Antonsen S.
International normalized ratio for prothrombin
times in patients taking oral anticoagulants:
critical difference and probability of signi-
ficant change in consecutive measurements.
Clin Chem. 1995 Mar;41(3):444-7.
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