COVID-19 Pneumonia:
Procalcitonin (PCT) for Risk Assessment and Rule-out of Bacterial Coinfection
on admission
PCT
during hospital stay
PCT
low risk for bacterial coin-
fection and adverse outcome
high risk patients, bacterial
coinfection likely
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© 2020 Thermo Fisher Scientific Inc. All rights reserved. B·R·A·H·M·S PCT and all other trademarks are the property of Thermo Fisher Scientific and its subsidiaries unless otherwise specified. ADVIA
Centaur and Atellica IM are registered and protected trademarks belonging to Siemens Healthcare Diagnostics. ADVIA Centaur B·R·A·H·M·S PCT and Atellica IM B·R·A·H·M·S PCT are products of
Siemens Healthcare Diagnostics licensed from Thermo Fisher Scientific. ALINITY i and ARCHITECT B·R·A·H·M·S PCT are products of Abbott
licensed from Thermo Fisher Scientific. Elecsys is a registered and protected trademark belonging to Roche or one of its subsidiaries. Elecsys
B·R·A·H·M·S PCT is a product of Roche licensed from Thermo Fisher Scientific. LIAISON is a registered and protected trademark belonging to
DiaSorin S.p.A. LIAISON B·R·A·H·M·S PCT II GEN is a product of DiaSorin S.p.A. licensed from Thermo Fisher Scientific. Lumipulse is a
registered trademark of Fujirebio Inc. in Japan and in other countries. Lumipulse G B·R·A·H·M·S PCT is a product of Fujirebio Inc. licensed from
Thermo Fisher Scientific. VIDAS is a registered trademark of bioMérieux S.A. or one of its subsidiaries. VIDAS B·R·A·H·M·S PCT is a product of
bioMérieux licensed from Thermo Fisher Scientific. VITROS is a trademark of Ortho Clinical Diagnostics. VITROS B·R·A·H·M·S PCT is a product
of Ortho Clinical Diagnostics licensed from Thermo Fisher Scientific. KRYPTOR is a trademark of Cisbio Bioassays, licensed for use by
B·R·A·H·M·S GmbH, a part of Thermo Fisher Scientific.
Patents:
901134.1
Thermo Fisher Scientific
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16761 Hennigsdorf
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Clinical Diagnostics
Find out more at
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*
Majority of patients with mild disease had PCT values <0.25 µg/L or even <0.1 µg/L.
Ref-1-6
Likelihood of bacterial infection and recommendation to start antibiotics in patients with LRTI at PCT 0.25 µg/L.
Ref-7
COVID-19
Test PCT as an aid for
early
risk assessment
and prioritization of
high
risk patients
Monitor PCT to detect:
References
Ref-1: Huang C et al: Lancet 2020; 395: 497–506
Ref-2: Guan W. et al., NEJM 28 Feb 2020,
Ref-3: Zhou et al., Lancet , March 9, 2020 ,
Ref-4: Chen N. et al., Lancet 2020; 395: 507–13
Ref-5: Xiao-Wei, X. et al., BMJ (Online); London 2020, 368 (Feb 19, 2020).DOI:10.1136/bmj.m606
Ref-6: Huang Y et al., medRxiv preprint 2020, doi:
Ref-7: Schuetz P. et al., Exp. Rev Anti-infect. Ther., 2018, 16:7, 555-564, DOI: 10.1080/14787210.2018.1496331
secondary bacterial infections
progression of disease
<0.5 µg/L*
≥0.5 µg/L
