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| 3 | 2009
Klinisk Biokemi i Norden
A taste of the scientific program
Plenary Lecture: Autoimmunity:
Lessons from Coeliac Disease
Professor Ludvig M. Sollid, is
the leader of Centre for Immune
Regulation, Institute of Immu-
nology, University of Oslo and
Oslo University Hospital – Riks
hospitalet, Oslo, Norway. He has
been working with the basic im-
mune and molecular mecha-
nisms involved in coeliac disease
for more than 25 years and has
been able to resolve many of its
puzzling features.
Coeliac disease is an HLA-associated disorder of
the small intestine which is caused by an inappro-
priate immune response to ingested gluten proteins.
Clearly this is a food hypersensitivity disorder, but at
the same time the disease has several autoimmune
features.
The understanding of the pathogenesis of coeliac
disease has made huge advances in recent years.
This immune response is controlled by CD4+ T cells
in the lamina propria that recognise gluten pep-
tides in the context of disease predisposing HLA-
molecules DQ2 or DQ8. These T cells are specific for
proline- and glutamine-rich gluten peptides that are
resistant to proteolysis and that have been become
posttranslationally modified (deamidated) by the
enzyme transglutaminase 2 (TG2). Strikingly, coe-
liac disease patients produce antibodies to this same
enzyme when exposed to dietary gluten. Professor
Sollid will discuss how the new insight in the patho-
genesis of coeliac disease may help us to understand
autoimmunity.
Vikingskipshuset
The Viking Ship Museum
Labmed 2010
News
Nr. 3
XXXII Nordic Congress in Medical Biochemistry
Facts of today – visions for tomorrow
Oslo, June 1-4 2010
General information
The planning of the scientific program, of the social activities, housing, invitation to
sponsors and exhibitors are on the track according to our time schedule.
Find updated information on
www.labmed2010.no
The Viking Ship Museum at Bygdøy
Foto: Gunnar Strom, VisitOslo
Ludvig Sollid
The Viking Ship Museum presents great viking ship
discoveries from Gokstad, Oseberg and Tune as well
as other finds from viking tombs around the Oslo
Fjord. The world's two best-preserved wooden viking
ships built in the 9th century are exhibited along
with small boats, sledges, cart with exceptional orna-
mentation, implements, tools, harness, textiles and
household utensils.
